Synthesis and structure of 6‐ and 7‐(acylmethyl)pteridines | Zendy

AbdelHady Sayed A. L. | Zendy; Badawy Mohamed A. | Zendy; Mosselhi Mosselhi A. N. | Zendy; Ibrahim Yehia A. | Zendy

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Synthesis and structure of 6‐ and 7‐(acylmethyl)pteridines

Author(s) -

AbdelHady Sayed A. L.,

Badawy Mohamed A.,

Mosselhi Mosselhi A. N.,

Ibrahim Yehia A.

Publication year - 1985

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570220337

Subject(s) - chemistry , hydrochloric acid , condensation , hydrolysis , derivative (finance) , pyridine , organic chemistry , physics , financial economics , economics , thermodynamics

6‐(Acylmethyl)‐7‐hydroxypteridines 7‐14 as well as the isomeric 7‐(acylmethyl)‐6‐hydroxypteridines 15‐22 were prepared by condensation of 5,6‐diaminouracils 1 and 2 with ethyl aroylpyruvates 3‐6 in pyridine and hydrochloric acid, respectively. The structures of the newly synthesized compounds were confirmed by their hydrolysis into the 7‐hydroxy‐6‐methyl‐ 23 , 24 and 6‐hydroxy‐7‐methylpteridines 25 and 26 . The synthesis of the 2‐(methylthio) derivative 28 is also described.

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