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Synthesis and structure of 6‐ and 7‐(acylmethyl)pteridines
Author(s) -
AbdelHady Sayed A. L.,
Badawy Mohamed A.,
Mosselhi Mosselhi A. N.,
Ibrahim Yehia A.
Publication year - 1985
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570220337
Subject(s) - chemistry , hydrochloric acid , condensation , hydrolysis , derivative (finance) , pyridine , organic chemistry , physics , financial economics , economics , thermodynamics
6‐(Acylmethyl)‐7‐hydroxypteridines 7‐14 as well as the isomeric 7‐(acylmethyl)‐6‐hydroxypteridines 15‐22 were prepared by condensation of 5,6‐diaminouracils 1 and 2 with ethyl aroylpyruvates 3‐6 in pyridine and hydrochloric acid, respectively. The structures of the newly synthesized compounds were confirmed by their hydrolysis into the 7‐hydroxy‐6‐methyl‐ 23 , 24 and 6‐hydroxy‐7‐methylpteridines 25 and 26 . The synthesis of the 2‐(methylthio) derivative 28 is also described.