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Synthesis of 1,2‐disubstituted isoindoles from o‐phthalaldehyde and primary amines
Author(s) -
Nan'ya Seiko,
Tange Toshiaki,
Maekawa Eturô
Publication year - 1985
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570220248
Subject(s) - chemistry , o phthalaldehyde , alkyl , primary (astronomy) , ethanol , organic chemistry , medicinal chemistry , combinatorial chemistry , high performance liquid chromatography , derivatization , physics , astronomy
2‐Alkyl‐1(2‐formylphenyl‐ N ‐alkyliminomethyl)isoindoles were prepared by the reaction of o‐phthaldehyde with primary amines in 99% ethanol at 0°. 2‐Alkyl‐3‐alkyliminoisoindolinones were isolated from the reaction mixture as by‐products. Their formation mechanism is proposed.