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Novel nucleophilic substitution of alkyl bromo‐2(1 H )‐pyridones
Author(s) -
Pessolano A. A.,
Witzel B. E.,
Graham P. M.,
Clark R. L.,
Jones H.,
Dorn C. P.,
Carty J.,
Shen T. Y.
Publication year - 1985
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570220205
Subject(s) - chemistry , nucleophile , ring (chemistry) , alkyl , nucleophilic substitution , bromine , medicinal chemistry , substitution reaction , stereochemistry , organic chemistry , catalysis
Nucleophilic substitution of certain alkyl bromo‐2(1 H )‐pyridones gave some unexpected products where the alkyl group is substituted and the ring bromine is replaced by hydrogen. The expected ring substituted product is also formed, but only as the minor product in most cases. Many reactions are cited with various nucleophiles, and a plausible mechanism is also presented.