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The 1,3,4‐oxadiazole moiety, a protective synthon for indirect radioiodination
Author(s) -
Heindel Ned D.,
Van Dort Marcian,
Cahn Maurice,
Schneider Richard,
Burns H. Donald
Publication year - 1985
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570220149
Subject(s) - moiety , chemistry , synthon , oxadiazole , halogenation , hydrolysis , condensation reaction , condensation , organic chemistry , catalysis , physics , thermodynamics
2‐(4‐Hydroxyphenyl)‐1,3,4‐oxadiazole can readily be iodinated/radioiodinated to 2‐(3,5‐diiodo‐4‐hydroxy‐phenyl)‐1,3,4‐oxadiazole which in a one‐step hydrolysis‐condensation serves as an indirect prosthetic moiety for iodination of carbonyl compounds.