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Fluorinated heterocyclic compounds. 2 . 2,4‐difluoro and 4‐amino‐2‐fluoropyrimidines, nucleoside base analogs
Author(s) -
Svirskaya Polina I.,
Yedidia Varda,
Leznoff Clifford C.,
Miller Jack M.
Publication year - 1985
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570220137
Subject(s) - chemistry , uracil , cytosine , thymine , nucleoside , base (topology) , stereochemistry , combinatorial chemistry , nucleoside analogue , biochemistry , dna , mathematical analysis , mathematics
Nucleoside base analogs in which fluoro substituents replace the enolic hydroxy groups of uracil, thymine and cytosine have been prepared. Improved methods for the preparation and isolation of the known 2,4‐di‐fluoropyrimidine, 2,4‐difluoro‐6‐methylpyrimidine and the new 2,4‐difluoro‐5‐methylpyrimidine, 2‐fluoro‐4‐aminopyrimidine, 4‐fluoro‐2‐aminopyrimidine, and other alkylaminofluoropyrimidines are described.