Premium
Diels‐alder cycloadditions of diene‐substituted N ‐ethoxycarbonyl‐2‐methyl‐1,2‐dihydropyridines with N ‐phenylmaleimide
Author(s) -
Krow Grant R.,
Can Kevin C.,
Carey James T.,
Lee Yoon B.,
Szczepanski Steven W.,
Ramjit Harri G.
Publication year - 1985
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570220133
Subject(s) - chemistry , diene , medicinal chemistry , dihydropyridine , alkyl , diels–alder reaction , bicyclic molecule , cycloaddition , organic chemistry , catalysis , calcium , natural rubber
The ten possible substitution patterns for N ‐Ethoxycarbonyl‐2‐methyl‐1,2‐dihydropyridines 5 in which one or two olefinic sites are alkyl substituted were synthesized and reacted with N ‐phenylmaleimide 2 to provide cycloadducts 6. N ‐Ethoxycarbonyl‐5,6‐cyclohexyl‐2‐methyl‐1,2‐dihydropyridine 51 provided the novel spirocycle 61.