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A new synthesis of 5,7‐dicarboxy‐2,1‐benzisoxazolin‐3‐one
Author(s) -
Kim C. K.,
Krasavage B. A.,
Maggiulli C. A.
Publication year - 1985
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570220131
Subject(s) - chemistry , condensation , hydrolysis , simple (philosophy) , organic chemistry , stereochemistry , medicinal chemistry , philosophy , physics , epistemology , thermodynamics
Condensation of methyl 2‐isoxazolin‐5‐on‐3‐yl acetate ( 3 ) and 3‐( N,N ‐dimethylamino)‐2‐ethoxycarbonylacrolein ( 6 ) gave 5‐ethoxycarbonyl‐7‐methoxycarbonyl‐2,1‐benzisoxazolin‐3‐one ( 7a ). Simple hydrolysis of the diester 7a afforded 5,7‐dicarboxy‐2,1‐benzisoxazolin‐3‐one ( 7b ).