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Synthesis using pyridinium anhydrobases, preparation of indolizine derivatives
Author(s) -
Molina P.,
Fresneda P. M.,
Lájara M. C.
Publication year - 1985
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570220129
Subject(s) - indolizine , chemistry , pyridinium , acylation , ring (chemistry) , medicinal chemistry , combinatorial chemistry , organic chemistry , catalysis
A number of derivatives of indolizine ring system have been prepared from 1‐substituted 4,6‐diphenyl‐2‐phenacylidene‐1,2‐dihydropyridines either by metallation with LDA or acylation and further basic treatment. Similarly, I‐arylmethyl‐4,6‐diphenyl‐2‐dicyanomethylene‐1,2‐dihydropyridines by action of LDA undergo cyclization to the corresponding 2‐amino‐1‐cyano‐3‐aryl indolizines.

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