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Synthesis of 4‐(4‐iodophenyl)piperazine and the 1‐carboxamidino derivative
Author(s) -
Hanson Robert N.,
Hariharan Shankar,
Astik Ramesh
Publication year - 1985
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570220112
Subject(s) - piperazine , chemistry , yield (engineering) , derivative (finance) , sulfate , medicinal chemistry , combinatorial chemistry , stereochemistry , organic chemistry , materials science , economics , financial economics , metallurgy
The previously unreported 4‐(4‐iodophenyl)piperazine ( 2 ) was synthesized in a 70% yield and characterized. The reaction of 2 with S ‐methylthiouronium sulfate gave the corresponding carboxamidino derivative 4 in a 61% yield. The tlc properties of 4 were identical with those of the radioiodinated material that had been prepared and evaluated as a potential myocardial imaging radiopharmaceutical.