Synthesis of 4‐(4‐iodophenyl)piperazine and the 1‐carboxamidino derivative | Zendy

Hanson Robert N. | Zendy; Hariharan Shankar | Zendy; Astik Ramesh | Zendy

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Synthesis of 4‐(4‐iodophenyl)piperazine and the 1‐carboxamidino derivative

Author(s) -

Hanson Robert N.,

Hariharan Shankar,

Astik Ramesh

Publication year - 1985

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570220112

Subject(s) - piperazine , chemistry , yield (engineering) , derivative (finance) , sulfate , medicinal chemistry , combinatorial chemistry , stereochemistry , organic chemistry , materials science , economics , financial economics , metallurgy

The previously unreported 4‐(4‐iodophenyl)piperazine ( 2 ) was synthesized in a 70% yield and characterized. The reaction of 2 with S ‐methylthiouronium sulfate gave the corresponding carboxamidino derivative 4 in a 61% yield. The tlc properties of 4 were identical with those of the radioiodinated material that had been prepared and evaluated as a potential myocardial imaging radiopharmaceutical.

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