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Synthesis of new derivatives of 4‐amino‐2,4‐dihydro‐1,2,4‐triazol‐3‐one as potential antibacterial agents
Author(s) -
Malbec Frédérique,
Milcent René,
Vicart Patrick,
Bure Anne Marie
Publication year - 1984
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570210641
Subject(s) - chemistry , alkyl , nitro , aryl , proton nmr , antibacterial activity , staphylococcus aureus , elemental analysis , stereochemistry , medicinal chemistry , combinatorial chemistry , organic chemistry , bacteria , biology , genetics
Thirty new 2‐substituted‐4‐amino‐5‐alkyl or aryl‐2,4‐dihydro‐1,2,4‐triazol‐3‐ones and ten 2‐substituted‐5‐alkyl or aryl‐4‐(5‐nitro‐2‐furfurylidene)amino‐2,4‐dihydro‐1,2,4‐triazol‐3‐ones were synthesized and characterised by their sharp melting points, elemental analysis, ir and 1 H nmr spectra. These new derivatives of 5‐nitro‐2‐furaldehyde were screened for their antibacterial activities. Most of the compounds showed good activity against one test organism, Staphylococcus aureus. For a few compounds, C.M.I. ranged from 4 to 8 μg/ml (higher results than nitrofurantoin).