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The synthesis of some derivatives of benzo[ f ]naphtho[1,8‐ bc ]thiepin‐12‐one
Author(s) -
Flores Maria Celia,
Beller Nicholas R.,
Castrillón JosÉ
Publication year - 1984
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570210633
Subject(s) - chemistry , benzene , halogen , medicinal chemistry , hydrogen peroxide , phosphorus pentoxide , organic chemistry , alkyl
The preparations of benzo[ f ]naphtho[1,8‐ bc ]thiepin‐12‐one, its 6‐methyl and 6‐methoxy derivatives and their corresponding sulfoxides and sulfones are described. They involve the coupling of suitable halogen naphthyl derivatives with thiophenoxides with the help of copper and the cyclization of the resulting acids with phosphorus pentoxide in benzene. The oxidations to sulfoxides and sulfones were performed with iodo‐benzene diacetate and hydrogen peroxide, respectively. The ir and pmr spectra are reported.