Pyridazines. XXIII  . A novel pyridazine into pyrazole ring transformation | Zendy

Heinisch Gottfried | Zendy; Waglechner Richard | Zendy

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Pyridazines. XXIII . A novel pyridazine into pyrazole ring transformation

Author(s) -

Heinisch Gottfried,

Waglechner Richard

Publication year - 1984

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570210631

Subject(s) - pyridazine , chemistry , pyrazole , ring (chemistry) , transformation (genetics) , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry , biochemistry , gene

Treatment of phenyl(4‐pyridazinyl)methanols 1a and 1b with p ‐toluenesulfonic acid at elevated temperatures causes transformation into the C‐4 substituted pyrazole derivatives 8a and 8b . Limitations of this novel rearrangement reaction as well as mechanistic considerations are discussed. Furthermore, the preparation of hitherto unknown 4‐pyridazinylmethanols 1b , 3 , and 7 is described.

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