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Synthesis of 6‐halogenated 4 H ‐1,4‐benzothiazines
Author(s) -
Gupta R. R.,
Kumar Rakesh,
Gautam R. K.
Publication year - 1984
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570210628
Subject(s) - chemistry , condensation , oxidative phosphorylation , proton nmr , mass spectrum , combinatorial chemistry , medicinal chemistry , organic chemistry , ion , biochemistry , physics , thermodynamics
The synthesis of 6‐halogenated 4 H ‐1,4‐benzothiazines is reported by the condensation and oxidative cyclization of 4‐substituted 2‐aminobenzenethiols (I, R = Cl, Br) with β‐diketones in presence of DMSO. The ir, nmr and mass spectral studies are included. 4‐Substituted 2‐aminobenzenethiols were also prepared by an improved and direct method.