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The synthesis of thienocycloheptenoindoles
Author(s) -
Abarca Belén,
Ballesteros Rafael,
Jones Gurnos
Publication year - 1984
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570210603
Subject(s) - chemistry , indole test , stereochemistry
Abstract A synthesis of the methylthieno[3,2‐ c ]cyclohepteno[ b ]indole 7 from 2‐methylthieno[3,2‐ b ]cycloheptanone 3 is described. Unsuccessful attempts to prepare the isomeric thienocycloheptenoindole system present in formula 2 , from the dihydrobenzothiophenone 8 , and from derivatives of 5‐(2‐thienyl)‐4‐oxopentanoic acid, 17 and 18 , and from N ‐benzylcycloheptindol‐1‐one 22 were unsuccessful. The preparation of 4,5‐dihydro‐2‐phenyl‐1‐thienylmethyl‐3 H ‐pyridazin‐3‐one 20 and of the 5‐aminopyrazole 21 are reported.