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Synthesis of 3‐amino‐2,4(1 H ,3 H )‐quinazolinediones for testing as anticonvulsants
Author(s) -
Kornet M. J.,
Varia T.,
Beaven W.
Publication year - 1984
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570210558
Subject(s) - chemistry , chloroformate , isocyanate , ethyl chloroformate , pyridine , anticonvulsant , medicinal chemistry , stereochemistry , organic chemistry , epilepsy , neuroscience , polyurethane , biology
A number of 3‐amino‐2,4(1 H ,3 H )‐quinazolinediones were synthesized from o ‐aminobenzoylhydrazines and ethyl chloroformate in pyridine or from 2‐methoxycarbonylphenyl isocyanate and 1,1‐disubstituted hydrazines. Four of the ten compounds screened exhibited anticonvulsant activity in mice.