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Some derivatives of morpholinophosphorodichloridate and dichloridothioate
Author(s) -
Cremlyn Richard J.,
Patel Kantilal,
Wu Luke
Publication year - 1984
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570210546
Subject(s) - chemistry , reagent , nucleophile , molar , molar ratio , primary (astronomy) , organic chemistry , medicinal chemistry , catalysis , medicine , physics , dentistry , astronomy
Morpholinophosphorodichloridate and dichloridothioate reacted with amines (2 molar equivalents) to give the amidic chlorides which were treated with nucleophilic reagents to give sixty‐four derivatives. However the dichloridothioate with primary amines (1 molar equivalent) only gave diamidic thioates, the reasons for the failure to obtain the expected amidochloridothioates are briefly discussed.