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Synthesis and anticonvulsant properties of a novel series of 2‐substituted amino‐5‐aryl‐1,3,4‐oxadiazole derivatives
Author(s) -
Omar A.Mohsen M. E.,
Aboulwafa Omaima M.
Publication year - 1984
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570210538
Subject(s) - oxadiazole , chemistry , aryl , anticonvulsant , series (stratigraphy) , oxide , combinatorial chemistry , organic chemistry , epilepsy , paleontology , alkyl , neuroscience , biology
Abstract A novel series of 2‐substituted amino‐5‐aryl‐1,3,4‐oxadiazole derivatives were synthesized for their potential anticonvulsant activity. The synthesis involved the cyclodesulfurization of variously substituted salicylthiosemicarbazides with DCCD and mercuric oxide. Representative examples of the title compounds were also prepared by a one‐pot cyclodesulfurization of mixtures of salicylhydrazides and phenylisothiocyanate with DCCD.