Premium
A novel synthesis for quinoline derivatives
Author(s) -
Fahmy A. M.,
Badr M. Z. A.,
Mohamed Y. S.,
AbdelLatif F. F.
Publication year - 1984
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570210462
Subject(s) - chemistry , malononitrile , ethyl acetoacetate , quinoline , acetonitrile , ethyl cyanoacetate , ring (chemistry) , medicinal chemistry , nucleophile , condensation , knoevenagel condensation , organic chemistry , catalysis , physics , thermodynamics
Condensation of ethyl 2‐(2‐oxo‐2,3‐dihydro‐1 H ‐indolid‐3‐ene)cyanoacetate and/or 2‐(2‐oxo‐2,3‐dihydro‐1 H ‐indolid‐2‐ene)malononitrile with 3‐methylpyrazolin‐5‐one, 1‐phenyl‐3‐methyl‐pyrazolin‐5‐one, benzoyl acetonitrile or ethyl acetoacetate affords different substituted quinolines. The reaction is suggested to proceed through a nucleophilic addition followed by ring opening and recyclization steps.