A novel synthesis for quinoline derivatives | Zendy

Fahmy A. M. | Zendy; Badr M. Z. A. | Zendy; Mohamed Y. S. | Zendy; AbdelLatif F. F. | Zendy

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A novel synthesis for quinoline derivatives

Author(s) -

Fahmy A. M.,

Badr M. Z. A.,

Mohamed Y. S.,

AbdelLatif F. F.

Publication year - 1984

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570210462

Subject(s) - chemistry , malononitrile , ethyl acetoacetate , quinoline , acetonitrile , ethyl cyanoacetate , ring (chemistry) , medicinal chemistry , nucleophile , condensation , knoevenagel condensation , organic chemistry , catalysis , physics , thermodynamics

Condensation of ethyl 2‐(2‐oxo‐2,3‐dihydro‐1 H ‐indolid‐3‐ene)cyanoacetate and/or 2‐(2‐oxo‐2,3‐dihydro‐1 H ‐indolid‐2‐ene)malononitrile with 3‐methylpyrazolin‐5‐one, 1‐phenyl‐3‐methyl‐pyrazolin‐5‐one, benzoyl acetonitrile or ethyl acetoacetate affords different substituted quinolines. The reaction is suggested to proceed through a nucleophilic addition followed by ring opening and recyclization steps.

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