Premium
A novel synthesis of precursors to 3‐thienylmalonic acid
Author(s) -
Raynolds Peter W.
Publication year - 1984
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570210461
Subject(s) - chemistry , sulfuryl chloride , dehydrohalogenation , yield (engineering) , pyridine , hydrolysis , organic chemistry , chloride , medicinal chemistry , catalysis , materials science , metallurgy
Methyl 2‐cyano‐2‐(3‐thienyl)acetate can be prepared in 95% yield by treating methyl 2‐cyano‐2‐(3‐tetra‐hydrothienylidene)acetate with sulfuryl chloride, followed by dehydrohalogenation with pyridine. The product can be hydrolyzed to 3‐thienylmalonic acid, a pharmaceutical intermediate.