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Synthesis of 3‐[(aryl)‐1,2,4‐oxadiazol‐5‐yl]propionic acids
Author(s) -
Srivastava Rajendra Mohan,
Viana Maria Benedita De Assunl̂t́o Borges,
Bieber Lothar
Publication year - 1984
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570210453
Subject(s) - chemistry , oxadiazole , succinic anhydride , aryl , mass spectrum , condensation , ring (chemistry) , proton nmr , base (topology) , medicinal chemistry , organic chemistry , polymer chemistry , stereochemistry , ion , mathematical analysis , alkyl , physics , thermodynamics , mathematics
Seven 3,5‐disubstituted oxadiazole derivatives, 3a‐g , have been prepared by direct condensation of appropriate benzamidoxime with succinic anhydride. Spectroscopic properties, especially uv, ir and mass spectra confirmed the cyclic 1,2,4‐oxadiazole structure. No ring‐opened intermediate or side product could be observed. The 1 H‐nmr assignments of the two CH 2 groups were unequivocally made by acid‐ and base‐induced shifts.