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Synthesis of 2‐aroylpiperazinyl‐4‐alkoxyquinazolines by phase‐transfer‐catalysed heteroaromatic nucleophilic substitution
Author(s) -
GÓmezGil M. C.,
GÓmezParra V.,
SÁnchez F.,
Torres T.
Publication year - 1984
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570210452
Subject(s) - chemistry , substituent , nucleophilic substitution , alkoxy group , chlorine , catalysis , medicinal chemistry , nucleophile , chlorine atom , substitution reaction , substitution (logic) , phase (matter) , stereochemistry , organic chemistry , alkyl , computer science , programming language
A series of quinazolines, with cardiovascular activity, having 2,3‐dihydroxypropoxy or 2‐hydroxy‐3‐ t ‐ butylaminopropoxy groups substituted at the 4‐position and chlorine or 2‐aroylpiperazinyl groups at the 2‐position have been synthesized. The introduction of the alkoxy substituent at C‐4 was carried out under phase‐transfer catalysis conditions.