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Non‐steroidal antiinflammatory agents. 1 . Synthesis of 4‐hydroxy‐2‐oxo‐1,2‐dihydroquinolin‐3‐yl alkanoic acids by the wittig reaction of quinisatines
Author(s) -
Faber Kurt,
StÚckler Hubert,
Kappe Thomas
Publication year - 1984
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570210450
Subject(s) - chemistry , wittig reaction , stereochemistry , reaction conditions , organic chemistry , medicinal chemistry , catalysis
The Wittig reaction of quinisatines ( 1a,b ) with 1‐ethoxycarbonylethyliden‐ ( 2a ) and ethoxycarbonylmeth‐ylenetriphenylphosphorane ( 2b ) has been investigated. In both cases unusual reaction products ( 3a,b and 12a,b respectively) were isolated in high yields and converted to potential antiinflammatory acids 6, 8, 15 and lactones 4 , 7.
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