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v ‐Triazolines. Part XIX . Thiocino[4,5‐ d ]‐1,2,3‐triazole and thiocino[4,5‐ d ]isoxazole derivatives
Author(s) -
Almirante Nicoletta,
Forti Luciana
Publication year - 1984
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570210438
Subject(s) - chemistry , isoxazole , nitrile , aryl , medicinal chemistry , organic chemistry , alkyl
5‐Amino‐2,3,6,7‐tetrahydrothiocines were reacted with arylazides yielding 1‐aryl‐9a‐amino‐1,3a,4,5,7,8,9,9a‐octahydrothiocino[4,5‐ d ]‐1,2,3‐triazoles which could be deaminated to 1‐aryl‐1,4,5,7,8,9‐hexahydrothiocino‐[4,5‐ d ]‐1,2,3‐triazoles. Similarly, the above enamines yielded, with nitrile oxides, 3‐aryl‐9a‐amino‐3a,4,5,8,9,9a‐hexahydrothiocino[4,5‐ d ]isoxazoles which were transformed with acids into 3‐aril‐4,5,8,9‐tetrahydrothiocino‐[4,5‐ d ]isoxazoles.