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Benzo[ b ]thiophene. Derivatives. XXVIII. 5‐bromo‐3‐benzo[ b ]thienylalanine and derivatives
Author(s) -
Campaigne E.,
Kim Chung S.
Publication year - 1984
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570210430
Subject(s) - chemistry , thiophene , hydrolysis , stereochemistry , medicinal chemistry , organic chemistry
A potential inhibitor of gelation of sickle hemoglobin, 5‐bromo‐3‐benzo[ b ]thienylalanine, has been synthesized along with several derivatives. Several hydrolytic pathways from the intermediate ethyl 5‐bromo‐3‐benzo[ b ]thienylformamidomalonate have been examined, and that involving alcoholysis to ethyl N‐formyl‐5‐bromo‐3‐benzo[ b ]thienylalanine shown to be superior.