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Synthesis of 1,2:5,6‐Di‐ O ‐isopropylidene‐3‐ O ‐[3‐(5‐fluorouracil‐1‐yl)‐propionoyi]‐α‐D‐glucofuranose and its antitumor activity
Author(s) -
Ouchi Tatsuro,
Jokei Satoshi,
Fujie Hirotoshi,
Chikashita Hidenori,
Inoi Takeshi
Publication year - 1984
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570210419
Subject(s) - chemistry , fluorouracil , derivative (finance) , stereochemistry , medicinal chemistry , chemotherapy , medicine , financial economics , economics
In order to provide a less toxic 5‐fluorouracil derivative, 1,2:5,6‐di‐ O ‐isopropylidene‐3‐ O ‐[3‐(5‐fluorouracill‐yl)‐propionoyl]‐α‐D‐glucofuranose, which was the derivative of 5‐fluorouracil combining indirectly to 3‐position of diacetoneglucose, was synthesized, and its antitumor activity was tested.