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Reduction of the benzoyl group in substituted 5‐benzoyl‐4,5‐dihydro‐1,2,4‐oxadiazoles
Author(s) -
Alcaide Benito,
Escobar Gerardo,
PérezOssorio Rafael,
Plumet Joaquin
Publication year - 1984
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570210361
Subject(s) - chemistry , lithium (medication) , hydride , aluminum hydride , ring (chemistry) , lithium aluminium hydride , medicinal chemistry , reduction (mathematics) , lithium hydride , organic chemistry , metal , ion , ionic bonding , medicine , endocrinology , methoxide , geometry , mathematics
The carbonyl group of substituted 5‐benzoyl‐4,5‐dihydro‐1,2,4‐oxadiazoles can be reduced by lithium aluminium hydride at low temperature without ring opening. Mixtures of the two related diastereoisomeric benzylalcohols are obtained. Configurations were assigned by 1 H‐nmr.