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The regioselective alkylation of 4,6‐dimethyl‐1‐phenyl‐2(1 H )‐pyrimidinone
Author(s) -
Katoh Akira,
Omote Yoshimori,
Kashima Choji
Publication year - 1984
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570210359
Subject(s) - chemistry , alkylation , halide , regioselectivity , alkyl , sodium hydride , medicinal chemistry , pyrimidinones , organic chemistry , catalysis
4,6‐Dimethyl‐1‐phenyl‐2(1 H )‐pyrimidinone (I) was treated with alkyl halides in the presence of sodium hydride at low temperature to afford only C‐6 alkylated products III and IV in good yields. Further, the mono‐, IIIa‐d, and di‐alkylated 2(1 H )‐pyrimidinones IVa‐d were selectively obtained by changing the amount of alkyl halides.