Synthesis of 5 H ‐10,11‐dihydropyrazolo[5,1‐ c ]‐[1,4]benzodiazepinederivatives. II | Zendy

Melani Fabrizio | Zendy; Cecchi Lucia | Zendy; Filacchioni Guido | Zendy

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Synthesis of 5 H ‐10,11‐dihydropyrazolo[5,1‐ c ]‐[1,4]benzodiazepinederivatives. II

Author(s) -

Melani Fabrizio,

Cecchi Lucia,

Filacchioni Guido

Publication year - 1984

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570210335

Subject(s) - chemistry , bromide , chloride , carboxylate , medicinal chemistry , bearing (navigation) , group (periodic table) , position (finance) , stereochemistry , organic chemistry , finance , economics , cartography , geography

Ethyl 3(5)‐formylpyrazole‐5(3)‐carboxylate, 2‐nitrobenzyl bromide or 2‐nitrobenzoyl chloride are the starting basic materials to prepare with a few reaction steps, pyrazolo[5,1‐ c ][1,4]benzodiazepines bearing at position 2 a substituted propionic chain ( 7–9 ) or bearing at position 5 a carbonyl group ( 12 ). Compounds 7–9, 12 are to be considered aza analogs of the antitumor antibiotic antramycin.

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