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Polycondensed nitrogen heterocycles. Part 13 . Pyrrolo[3,2‐ b ]indole by intramolecular nucleophilic substitution reaction in the pyrrole series
Author(s) -
Aiello E.,
Dattolo G.,
Cirrincione G.,
Almerico A. M.
Publication year - 1984
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570210318
Subject(s) - chemistry , intramolecular force , nucleophilic substitution , indole test , bromine , pyrrole , nucleophile , chlorine , medicinal chemistry , substitution reaction , nitro , intramolecular reaction , stereochemistry , organic chemistry , catalysis , alkyl
An intramolecular nucleophilic substitution in the pyrrole series has been generalized. The behaviour of nitro, chlorine, bromine and iodine as leaving groups towards the nucleophilic amino group was observed. An acid catalyzed mechanism has been proposed.