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The synthesis of substituted pyrido[1′,2′:1,5]pyrazolo[3,4‐ d ]pyrimidines
Author(s) -
Molina P.,
Arques A.,
Hernandez H.
Publication year - 1984
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570210311
Subject(s) - chemistry , triethylamine , carbon disulfide , ring (chemistry) , pyrimidine , pyridine , aryl , dimethylformamide , hydrogen sulfide , medicinal chemistry , disulfide bond , organic chemistry , stereochemistry , sulfur , solvent , alkyl , biochemistry
A convenient synthesis of derivatives of the pyrido[1′,2′:1,5]pyrazolo[3,4‐ d ]pyrimidine ring system from readily available 2‐amino‐3‐cyano‐5,7‐diphenylpyrazolo[1,5‐ a ]pyridine I and carbon disulfide, aryl isothiocyanates or nitriles is described. Derivatives of compound I undergo cyclization to the titled ring system by action of dimethylformamide dimethylacetal or hydrogen sulfide followed by treatment with triethylamine.