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Aminoalkyl derivatives of 2,4′‐bithiazole‐4‐carboxylic acid, the intercalating part of bleomycin
Author(s) -
Houssin Raymond,
Bernier JeanLuc,
Hénichart JeanPierre
Publication year - 1984
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570210310
Subject(s) - chemistry , moiety , thiazole , bleomycin , stereochemistry , intercalation (chemistry) , carboxylate , carboxylic acid , organic chemistry , chemotherapy , medicine , surgery
The synthesis of three 2,4′‐bithiazole derivatives related to the antibiotic antitumor bleomycin is reported. These compounds substituted by aminoalkyl chains on 2′ and/or 4‐positions were prepared by the Hantzs synthesis between new thioamides and methyl 2‐(2‐bromoacetyl)thiazole‐4‐carboxylate and will be useful for the study of the intercalative moiety of bleomycin.