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Substituted 5‐( D,L ‐ erythro ‐1′,2′‐dihydroxypropyl)pyrazines. Potential precursors for the synthesis of biopterin derivatives
Author(s) -
Pastor Stephen D.,
Nelson Aaron L.
Publication year - 1984
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570210306
Subject(s) - chemistry , diastereomer , decarboxylation , biopterin , stereochemistry , organic chemistry , combinatorial chemistry , catalysis , cofactor , tetrahydrobiopterin , enzyme
A convenient synthesis of substituted 5‐( D,L )‐ erythro ‐1′,2′‐dihydroxypropyl)pyrazines from crotonic acid 4 is described. The anomalous behavior during decarboxylation of functionalized 2‐oximino‐3‐oxoesters 8a,b is noted. The structures of prepared compounds were determined by spectroscopic methods.