Phase transfer catalysis in  N ‐alkylation of the pharmaceutical intermediates phenothiazine and 2‐chlorophenothiazine | Zendy

Gozlan Igal | Zendy; Ladkani David | Zendy; Halpern Mark | Zendy; Rabinovitz Mordecai | Zendy; Avnir David | Zendy

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Phase transfer catalysis in N ‐alkylation of the pharmaceutical intermediates phenothiazine and 2‐chlorophenothiazine

Author(s) -

Gozlan Igal,

Ladkani David,

Halpern Mark,

Rabinovitz Mordecai,

Avnir David

Publication year - 1984

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570210271

Subject(s) - chemistry , alkylation , phenothiazine , yield (engineering) , catalysis , phase (matter) , combinatorial chemistry , organic chemistry , medicinal chemistry , thermodynamics , pharmacology , medicine , physics

The N ‐alkylation of the two title compounds was studied, utilizing phase transfer catalysis (PTC) methods. Very mild reaction conditions were developed, especially for three‐carbon N ‐alkylation. Of special interest is the high‐yield synthesis of N ‐(3‐chloropropyl)‐2‐chlorophenothiazine. The results are discussed in terms of the classical PTC/OH − mechanisms.

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