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Dehydrogenation reactions of 1‐substituted‐3‐aryltetrahydroisoquinoline derivatives
Author(s) -
Domínguez Esther,
Lete Esther
Publication year - 1984
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570210252
Subject(s) - chemistry , dehydrogenation , isoquinoline , oxidizing agent , iodine , salt (chemistry) , palladium , organic chemistry , ethanol , medicinal chemistry , catalysis
The 1‐substituted‐3‐aryltetrahydroisoquinolines I have been converted into the corresponding 3,4‐dihydroor isoquinoline derivatives by treatment with several oxidizing agents: iodine in ethanol, palladium on carbon, DDQ and Fremy's salt. The oxidation reactions with iodine always resulted in the formation of the 3,4‐dihydroisoquinolines II, whereas the use of palladium on carbon and the DDQ led to the aromatic isoquinolines. Both the 3,4‐dihydro‐ and the isoquinoline derivatives were obtained by means of Fremy's salt.