The reaction of 2‐indolecarbohydrazones with ethoxycarbonyl chloride. New synthesis of 2,3‐dihydro‐2‐oxo‐1,3,4‐oxadiazoles and 1,2,3,4‐tetrahydro‐4‐oxo‐5 H ‐pyridazino[4,5‐ b ]indoles | Zendy

Monge A. | Zendy; Palop J. A. | Zendy; Tabar P. | Zendy; FernándezAlvarez E. | Zendy

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The reaction of 2‐indolecarbohydrazones with ethoxycarbonyl chloride. New synthesis of 2,3‐dihydro‐2‐oxo‐1,3,4‐oxadiazoles and 1,2,3,4‐tetrahydro‐4‐oxo‐5 H ‐pyridazino[4,5‐ b ]indoles

Author(s) -

Monge A.,

Palop J. A.,

Tabar P.,

FernándezAlvarez E.

Publication year - 1984

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570210225

Subject(s) - chemistry , chloride , medicinal chemistry , combinatorial chemistry , organic chemistry

The synthesis of 2,3‐dihydro‐2‐oxo‐1,3,4‐oxadiazole ( 4 ) and 5 H ‐pyridazino[4,5‐ b ]indole ( 7 ), are described. Compounds 4 were obtained by reduction of O ‐ethoxycarbonylcarbohydrazones 3 with sodium borohydride. Compounds 7 were obtained by cyclization of compounds with ethanol/hydrochloric acid and removing the ethoxycarbonyl group with hydrazine. Compounds 3 were obtained by reaction of 2‐indolecarbohydrazones 1 with ethoxycarbonyl chloride.

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