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Synthesis of 3 H [1,2]diazepino[5,6‐ b ]indole and 3 H [1,2]diazepino[4,5‐ b ]indole derivatives
Author(s) -
Monge A.,
Palop J. A.,
Goñi T.,
Martinez A.,
FernándezAlvarez E.
Publication year - 1984
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570210221
Subject(s) - chemistry , hydrazine (antidepressant) , indole test , formylation , acetonitrile , derivative (finance) , medicinal chemistry , organic chemistry , stereochemistry , catalysis , chromatography , financial economics , economics
The synthesis of two new derivatives of 3 H [1,2]diazepino[5,6‐ b ]indole, 5 and 11 , and one new derivative of 3 H [1,2]diazepino[4,5‐ b ]indole, 16 , are described. Compound 5 was obtained by the reaction of methyl 2‐(3‐methoxycarbonyl‐1‐methylindole)acetate 2 , with hydrazine. Compound 11 was obtained in two ways from ethyl 2‐(1‐methylindole)acetate ( 8 ) by formylation and reaction with hydrazine. Compound 16 was obtained treating 3‐(2‐ethoxycarbonylindole)acetonitrile ( 14 ) with hydrazine.