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Imidazolyl derivatives of the chroman ring. 1
Author(s) -
Cozzi Paolo,
Mongelli Nicola,
Pillan Antonio
Publication year - 1984
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570210208
Subject(s) - chemistry , ring (chemistry) , closure (psychology) , benzopyran , stereochemistry , medicinal chemistry , organic chemistry , economics , market economy
The synthesis of 2‐(1 H ‐imidazol‐1‐yl)‐2,3‐dihydro‐2 H ‐1‐benzopyran‐4‐ones (I) through 3‐bromo‐2,3‐dihydro‐4 H ‐1‐benzopyran‐4‐ones or more conveniently through chroman ring closure from 2‐(1 H ‐imidazol‐1‐yl)‐2′‐hydroxyacetophenones is described. The ring closure also works well for the pyrazolyl derivatives. Compounds I and the corresponding imidazolylchromanols, ‐chromenes, and ‐chromans derived from the former, were pharmacologically investigated.