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Synthesis of α‐Oxo and α‐hydroxy‐1‐benzyl‐1,4‐dihydro‐3(2 H )‐isoquinolinones
Author(s) -
Sanna Paolo,
Savelli Francesco
Publication year - 1984
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570210205
Subject(s) - chemistry , depressant , organic chemistry , stereochemistry , pharmacology , medicine
The reaction of some primary amines with the methyl 2‐[(α‐oxobenzyl)‐(α‐bromo)methyl]phenylacetate ( 5 ) afforded the isoquinolinones 7a‐d , which in turn were hydrogenated to 10a‐d . The synthesis of these compounds was designed on the basis of a potential depressant and antiinflammatory activity found in other structurally related compounds.