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Synthesis of 3,5‐disubstituted 1,3,4‐oxadiazole‐2‐thiones as potential fungicidal agents
Author(s) -
Goswami B. N.,
Kataky J. C. S.,
Baruah J. N.,
Nath S. C.
Publication year - 1984
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570210141
Subject(s) - chemistry , oxadiazole , alkyl , proton nmr , aryl , mass spectrum , elemental analysis , organic chemistry , medicinal chemistry , fungicide , carbon 13 nmr , botany , ion , biology
Sixteen new 3‐arylaminomethyl‐5‐(2,4‐dichlorophenyl)‐1,3,4‐oxadiazole‐2‐thione and six 3‐alkyl aryl alkyl‐5‐(2,4‐dichlorophenyl)‐1,3,4‐oxadiazole‐2‐thiones were synthesised and characterised by their sharp melting points, elemental analysis, ir, 1 H nmr and mass spectra. These substituted oxadiazolethiones were screened for their fungitoxic properties. Most of the compounds showed toxicity against two test organisms, Curvularia verruciformis and Alternaria tenuis . The degree of inhibition ranged from 38‐‐100% for a few compounds.