Premium
A versatile approach to analogues of the cannabinoid‐like anti‐emetic nonabine (BRL 4664)
Author(s) -
Gardner Derek V.,
Miller David
Publication year - 1984
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570210125
Subject(s) - chemistry , cannabinoid , resorcinol , aryl , stereochemistry , combinatorial chemistry , organic chemistry , biochemistry , alkyl , receptor
Analogues of the cannabinoid‐like anti‐emetic nonabine (BRL 4664), in which the 4‐pyridinyl and 1,2‐dimethylheptyl groups have been replaced by other aryl and alky groups respectively, have been synthesised from the appropriate resorcinol by a novel procedure. The route has been shown to be of general applicability, although in the case of nonabine itself the procedure does not represent a viable alternative to that previously published.