Premium
Pyridinethiones. IX preparation of ricinidine, thioricinidine and other 2(1 H )‐pyridones and ‐thiones related to nicotinic acid
Author(s) -
Becher Jan,
Johansen Tea,
Michael Maged Aziz
Publication year - 1984
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570210110
Subject(s) - chemistry , substituent , nicotinic agonist , electronegativity , peroxide , medicinal chemistry , organic chemistry , biochemistry , receptor
2(1 H )‐Pyridones and ‐thiones related to 1‐substituted nicotinic acid derivatives have been prepared via the corresponding l‐substituted‐3‐formyl‐2(1 H )‐pyridones and ‐thiones. A number of synthetic procedures for the interconversion of functional groups in these nicotinic acid derivatives are given i.e . preparation of the aldoximes, nitriles, carboxamides and carboxylic acids as well as the 3‐ hydroxyalkyl derivatives. The course of the basic peroxide oxidation of the l‐substituted‐3‐formyl‐2(1 H )‐pyridinethiones is found to be very dependent upon the electronegativity of the 1‐substituent. A preparation of ricinidine is also described.