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Preparation of phenylquinoxaline from α,α‐diaminoketones and dimethyl‐ O ‐phenylenediamine
Author(s) -
Saeed Ali A. H.,
Ebraheem Ebraheem K.
Publication year - 1983
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570200662
Subject(s) - chemistry , amination , yield (engineering) , phenylglyoxal , condensation , medicinal chemistry , organic chemistry , polymer chemistry , catalysis , metallurgy , biochemistry , materials science , physics , amino acid , arginine , thermodynamics
Amination of α,α‐diaminoketones 1 by 4,5‐dimethyl‐ o ‐phenylenediamine gave 6,7‐dimethyl‐2‐phenylquinoxaline (II) in a high yield. The reaction may occur through formation of α‐ketoazomethine III. The α,α‐di‐aminoketones were obtained by condensation of phenylglyoxal and substituted anilines.