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One‐pot synthesis and structure of 10‐heteroarylphenothiazines
Author(s) -
Jovanovic Misa V.,
Biehl Edward R.
Publication year - 1983
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570200647
Subject(s) - chemistry , phenothiazine , ring (chemistry) , crystal structure , ullmann reaction , stereochemistry , computational chemistry , crystallography , combinatorial chemistry , organic chemistry , catalysis , medicine , pharmacology
Novel 10‐heteroarylphenothiazine compounds were prepared in high yields by Ullmann coupling of the appropriate iodoheterocycle, prepared in situ , with a series of phenothiazines. The 13 C nmr analysis of titled compounds predicts geometries which are in excellent agreement with available x‐ray crystal structure data. The results also indicate significant π‐interaction between the electron‐rich phenothiazine ring and the π‐deficient heterocycles.