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A 13 C‐NMR assignment study of a series of 2,3,4,5‐tetrahydro‐1‐methyl‐1 H ‐1,5‐benzodiazepine‐2,4‐diones
Author(s) -
Aversa Maria Chiara,
Ferlazzo Alida,
Giannetto Placido
Publication year - 1983
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570200641
Subject(s) - chemistry , clobazam , benzodiazepine , series (stratigraphy) , spectral line , carbon 13 nmr , computational chemistry , stereochemistry , nmr spectra database , physics , paleontology , biochemistry , receptor , astronomy , neuroscience , epilepsy , biology
The natural abundance 13 C‐nmr spectra of a series of 2,3,4,5‐tetrahydro‐1‐methyl‐1 H ‐1,5‐benzodiazepine‐2,4‐diones have been recorded: two of these compounds, clobazam and triflubazam, are clinically used as psychotherapeutic agents. The assignments of the various resonances have been made by chemical shift arguments, by the analysis of the fine splittings caused by one bond and long range couplings, and also by comparison with model compounds.