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The synthesis of 4 H ‐imidazo[5,1‐c][1,4]benzothiazine derivatives
Author(s) -
Fryer R. Ian,
Lauer Rudolph F.,
Trybulski Eugene J.,
Vitone Stephen,
Walser Armin,
Zenchoff Gladys
Publication year - 1983
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570200635
Subject(s) - benzothiazine , chemistry , imidazole , ring (chemistry) , annulation , bicyclic molecule , stereochemistry , combinatorial chemistry , medicinal chemistry , organic chemistry , catalysis
A facile synthesis of the 4 H ‐imidazo[5,1‐ c ][1,4]benzothiazine ring system is described. The synthesis utilized the annulation of an imidazole ring onto a 2 H ‐1,4‐benzothiazin‐3(4 H )‐one via the addition of the anion of ethyl isocyanoacetate. Methods for the functionalization of the 1‐, 3‐, 4‐, and 5‐positions of the ring system are presented.