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On the syntheses of thiophene analogs of practolol and “reversed” practolol
Author(s) -
Casarrubio J. Luis,
Conde Santiago,
Corral Carlos,
Lissavetzky Jaime
Publication year - 1983
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570200624
Subject(s) - practolol , chemistry , thiophene , blocking (statistics) , combinatorial chemistry , stereochemistry , organic chemistry , medicine , propranolol , statistics , mathematics
Abstract The synthesis of the thiophene analogs of the cardio‐selective β‐adrenergic blocking agents Practolol and “reversed” Practolol has been attempted starting from 2‐acetyl‐5‐bromothiophene. Although this synthesis worked for the second compound it was not possible to obtain the first one. From this and other results of this paper it can be deduced that the thiophene analog of Practolol must be an unstable compound.