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Friedländer condensation of 1 H ‐pyrazolin‐5‐ones with O ‐aminobenzaldehydes. Synthesis of 1 H ‐pyrazolo[3,4‐ B ]quinolines
Author(s) -
Tomasik Danuta,
Tomasik Piotr,
Abramovitch Rudolph A.
Publication year - 1983
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570200620
Subject(s) - chemistry , condensation , hydrazone , ring (chemistry) , medicinal chemistry , catalysis , stereochemistry , organic chemistry , meteorology , physics
All the possible 1‐ and 3‐monomethyl, monophenyl, dimethyl, diphenyl, and methylphenyl‐1 H ‐pyrazolin‐5‐ones have been condensed with o ‐aminobenzaldehyde. In some cases (but not all) 1‐ H ‐pyrazolo[3,4‐ b ]quinolines (10) are formed together with a variety of other products. The balance between formation of hydrazone 11 and the ring‐closed 10 is discussed, as is the formation of other products obtained in these condensations.