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Synthesis of 1‐aryl‐3‐trifluoromethyl‐5‐methylthio‐1,2,4‐triazoles from 2‐arylmethylisothiosemicarbazides and 1,1,1‐trichloro‐3,3,3‐trifluoroacetone
Author(s) -
Pilgram Kurt H.,
Skiles Richard D.
Publication year - 1983
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570200619
Subject(s) - trifluoromethyl , chemistry , aryl , base (topology) , medicinal chemistry , organic chemistry , alkyl , mathematical analysis , mathematics
The reaction of 1,1,1‐trichloro‐3,3,3‐trifluoroacetone with S‐methyl‐2‐arylisothiosemicarbazides affords an unusual synthesis of 1‐aryl‐3‐trifluoromethyl‐5‐methylthio‐1,2,4‐triazoles from which 1‐aryl‐3‐trifluoromethyl‐1,2,4(4 H )‐triazole‐5‐ones are obtained on treatment with base.