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Synthesis of 4(5)‐hydroxymethylimidazoles by hydroxymethylation and decarboxylation of imidazole‐4(5)‐carboxylic acids
Author(s) -
Kim Choong S.,
Lee Kee J.,
Kim Hong S.,
Chae Yung B.
Publication year - 1983
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570200553
Subject(s) - chemistry , decarboxylation , imidazole , formaldehyde , carboxylic acid , aqueous solution , base (topology) , organic chemistry , catalysis , mathematical analysis , mathematics
4(5)‐Hydroxymethylimidazoles were prepared by hydroxymethylation and decarboxylation of imidazole‐4(5)‐carboxylic acid esters. The reaction was simply carried out with aqueous formaldehyde solution in the presence of base.