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Imdazole systems. I. Imidzo[2,1‐ b ][1,3,5]benzothiadiazepine derivatives as potential antipsychotic agents
Author(s) -
Vecchia Laurence Delia,
Dellureficio James,
Kisis Biruta,
Vlattas Isidoros
Publication year - 1983
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570200528
Subject(s) - chemistry , phosgene , ring (chemistry) , guanidine , antipsychotic , stereochemistry , combinatorial chemistry , medicinal chemistry , organic chemistry , schizophrenia (object oriented programming) , computer science , programming language
Imidazo[2,1‐ b ][1,3,5]benzothiadiazepine 3 constitutes a novel ring system, and its analogs 3a‐i were synthesized to investigate their potential antipsychotic activity. The synthesis of the ring system was achieved by reaction of 2‐aminophenylthioimidazoles 7 with phosgene or thiophosgene and by ring closure of the 1‐[2‐(2‐imidazolyl)thiophenyliminocarbonyl]‐1‐piperazines 13 . An efficient method for the conversion of thioureas 8, 12 to guanidine 3a via the corresponding cyanothioamidines 11, 14 was developed.